Adjuvants for coronavirus vaccines
Z Liang, H Zhu, X Wang, B Jing, Z Li, X Xia… - Frontiers in …, 2020 - frontiersin.org
Vaccine development utilizing various platforms is one of the strategies that has been
proposed to address the coronavirus disease 2019 (COVID-19) pandemic. Adjuvants are …
proposed to address the coronavirus disease 2019 (COVID-19) pandemic. Adjuvants are …
Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity
In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and
essentially used for enhanced and long-lasting protective immune responses. Depending …
essentially used for enhanced and long-lasting protective immune responses. Depending …
Virus-like particle-templated silica-adjuvanted nanovaccines with enhanced humoral and cellular immunity
M Li, Z Liang, C Chen, G Yu, Z Yao, Y Guo, L Zhang… - ACS …, 2022 - ACS Publications
Virus-like particles (VLPs) are self-assembled viral proteins that represent a superior form of
antigens in vaccine formulations. To enhance immunogenicity, adjuvants, especially the …
antigens in vaccine formulations. To enhance immunogenicity, adjuvants, especially the …
Designing a microbial fermentation-functionalized alginate microsphere for targeted release of 5-ASA using nano dietary fiber carrier for inflammatory bowel disease …
L Qiu, R Shen, L Wei, S Xu, W Xia, Y Hou, J Cui… - Journal of …, 2023 - Springer
Patients with inflammatory bowel disease (IBD) always suffer from severe abdominal pain
and appear to be at high risk for colorectal cancer. Recently, the co-delivery of targeted …
and appear to be at high risk for colorectal cancer. Recently, the co-delivery of targeted …
Nanoparticle-based adjuvants and delivery systems for modern vaccines
Ever since the development of the first vaccine, vaccination has had the great impact on
global health, leading to the decrease in the burden of numerous infectious diseases …
global health, leading to the decrease in the burden of numerous infectious diseases …
The crystallinity and aspect ratio of cellulose nanomaterials determine their pro‐inflammatory and immune adjuvant effects in vitro and in vivo
Nanocellulose is increasingly considered for applications; however, the fibrillar nature,
crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be …
crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be …
Mechanistic understanding of the aspect ratio-dependent adjuvanticity of engineered aluminum oxyhydroxide nanorods in prophylactic vaccines
Aluminum oxyhydroxide (AlOOH) adjuvants are widely used in human vaccines. However,
the interaction mechanisms at the material-bio interface, and further understandings on …
the interaction mechanisms at the material-bio interface, and further understandings on …
Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants
In modern vaccines, adjuvants can be sophisticated immunological tools to promote robust
and long-lasting protection against prevalent diseases. However, there is an urgent need to …
and long-lasting protection against prevalent diseases. However, there is an urgent need to …
Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of …
E Shardlow, M Mold, C Exley - Allergy, Asthma & Clinical Immunology, 2018 - Springer
Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only
two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and …
two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and …
Engineering aluminum hydroxyphosphate nanoparticles with well-controlled surface property to enhance humoral immune responses as vaccine adjuvants
Z Liang, Y Yang, G Yu, H Zhu, X Xia, C Chen, D Fu… - Biomaterials, 2021 - Elsevier
Aluminum phosphate adjuvants play a critical role in human inactivated and subunit
prophylactic vaccines. However, a major challenge is that the underlying mechanism of …
prophylactic vaccines. However, a major challenge is that the underlying mechanism of …