Adjuvants for coronavirus vaccines

Z Liang, H Zhu, X Wang, B Jing, Z Li, X Xia… - Frontiers in …, 2020 - frontiersin.org
Vaccine development utilizing various platforms is one of the strategies that has been
proposed to address the coronavirus disease 2019 (COVID-19) pandemic. Adjuvants are …

Vaccine adjuvants: Understanding the structure and mechanism of adjuvanticity

S Shi, H Zhu, X Xia, Z Liang, X Ma, B Sun - Vaccine, 2019 - Elsevier
In conjugate, inactivated, recombinant, and toxoid vaccines, adjuvants are extensively and
essentially used for enhanced and long-lasting protective immune responses. Depending …

Virus-like particle-templated silica-adjuvanted nanovaccines with enhanced humoral and cellular immunity

M Li, Z Liang, C Chen, G Yu, Z Yao, Y Guo, L Zhang… - ACS …, 2022 - ACS Publications
Virus-like particles (VLPs) are self-assembled viral proteins that represent a superior form of
antigens in vaccine formulations. To enhance immunogenicity, adjuvants, especially the …

Designing a microbial fermentation-functionalized alginate microsphere for targeted release of 5-ASA using nano dietary fiber carrier for inflammatory bowel disease …

L Qiu, R Shen, L Wei, S Xu, W Xia, Y Hou, J Cui… - Journal of …, 2023 - Springer
Patients with inflammatory bowel disease (IBD) always suffer from severe abdominal pain
and appear to be at high risk for colorectal cancer. Recently, the co-delivery of targeted …

Nanoparticle-based adjuvants and delivery systems for modern vaccines

B Filipić, I Pantelić, I Nikolić, D Majhen… - Vaccines, 2023 - mdpi.com
Ever since the development of the first vaccine, vaccination has had the great impact on
global health, leading to the decrease in the burden of numerous infectious diseases …

The crystallinity and aspect ratio of cellulose nanomaterials determine their pro‐inflammatory and immune adjuvant effects in vitro and in vivo

X Wang, CH Chang, J Jiang, Q Liu, YP Liao, J Lu, L Li… - Small, 2019 - Wiley Online Library
Nanocellulose is increasingly considered for applications; however, the fibrillar nature,
crystalline phase, and surface reactivity of these high aspect ratio nanomaterials need to be …

Mechanistic understanding of the aspect ratio-dependent adjuvanticity of engineered aluminum oxyhydroxide nanorods in prophylactic vaccines

Z Liang, X Wang, G Yu, M Li, S Shi, H Bao, C Chen… - Nano Today, 2022 - Elsevier
Aluminum oxyhydroxide (AlOOH) adjuvants are widely used in human vaccines. However,
the interaction mechanisms at the material-bio interface, and further understandings on …

Inflammasome-mediated immunogenicity of clinical and experimental vaccine adjuvants

S Reinke, A Thakur, C Gartlan, JS Bezbradica, A Milicic - Vaccines, 2020 - mdpi.com
In modern vaccines, adjuvants can be sophisticated immunological tools to promote robust
and long-lasting protection against prevalent diseases. However, there is an urgent need to …

Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of …

E Shardlow, M Mold, C Exley - Allergy, Asthma & Clinical Immunology, 2018 - Springer
Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only
two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and …

Engineering aluminum hydroxyphosphate nanoparticles with well-controlled surface property to enhance humoral immune responses as vaccine adjuvants

Z Liang, Y Yang, G Yu, H Zhu, X Xia, C Chen, D Fu… - Biomaterials, 2021 - Elsevier
Aluminum phosphate adjuvants play a critical role in human inactivated and subunit
prophylactic vaccines. However, a major challenge is that the underlying mechanism of …