Historically, the mammalian brain was thought to lack stem cells as no new neurons were
found to be made in adulthood. That dogma changed∼ 25 years ago with the identification …

The neocortex is considered the seat of higher cognitive function in humans. It develops
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …

The complexities of human neurodevelopment have historically been challenging to
decipher but continue to be of great interest in the contexts of healthy neurobiology and …

Neurons decline in their functionality over time, and age‐related neuronal alterations are
associated with phenotypes of neurodegenerative diseases. In nonneural tissues, an …

Neural induction is a process where naive cells are converted into committed cells with
neural characteristics, and it occurs at the earliest step during embryogenesis. Although the …

The hippocampus plays major roles in learning and memory, and its formation requires
precise coordination of patterning, cell proliferation, differentiation, and migration. Here we …

Recent studies have demonstrated that epigenetic modifications are deeply involved in
neurogenesis; however, the precise mechanisms remain largely unknown. To determine the …

RYBP (Ring1 and YY1 binding protein), an essential component of the Polycomb repressive
complex 1 (PRC1), plays pivotal roles in development and diseases. However, the roles of …

During brain development, neural precursor cells (NPCs) in different brain regions produce
different types of neurons, and each of these regions plays a different role in the adult brain …

During mammalian neurodevelopment, signaling pathways converge upon transcription
factors (TFs) to establish appropriate gene expression programmes leading to the …