Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity

R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

[HTML][HTML] Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)

M Bialer, SI Johannessen, RH Levy, E Perucca… - Epilepsy research, 2013 - Elsevier
The Eleventh Eilat Conference on New Antiepileptic Drugs (AEDs)-EILAT XI, took place in
Eilat, Israel from the 6th to 10th of May 2012. About 100 basic scientists, clinical …

Age matters

JE McCutcheon, M Marinelli - European Journal of …, 2009 - Wiley Online Library
The age of an experimental animal can be a critical variable, yet age matters are often
overlooked within neuroscience. Many studies make use of young animals, without …

Neuropeptides: opportunities for drug discovery

T Hökfelt, T Bartfai, F Bloom - The Lancet Neurology, 2003 - thelancet.com
The role of peptides as signalling molecules in the nervous system has been studied for
more than 30 years. Neuropeptides and their G-protein-coupled receptors are widely …

The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease

R Lang, AL Gundlach, B Kofler - Pharmacology & therapeutics, 2007 - Elsevier
The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

Hippocampal plasticity during the progression of Alzheimer's disease

EJ Mufson, L Mahady, D Waters, SE Counts, SE Perez… - Neuroscience, 2015 - Elsevier
Neuroplasticity involves molecular and structural changes in central nervous system (CNS)
throughout life. The concept of neural organization allows for remodeling as a compensatory …

Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments

LQ Zhu, SH Wang, D Liu, YY Yin, Q Tian… - Journal of …, 2007 - Soc Neuroscience
Activation of glycogen synthase kinase-3 (GSK-3) can cause memory deficits as seen in
Alzheimer's disease, the most common age-associated dementia, but the mechanism is not …

Galanin receptors and ligands

KEB Webling, J Runesson, T Bartfai… - Frontiers in …, 2012 - frontiersin.org
The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family
consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide …

[HTML][HTML] An overview of brain-derived neurotrophic factor and implications for excitotoxic vulnerability in the hippocampus

PS Murray, PV Holmes - International journal of peptides, 2011 - hindawi.com
The present paper examines the nature and function of brain-derived neurotrophic factor
(BDNF) in the hippocampal formation and the consequences of changes in its expression …

Epilepsy and Alzheimer's Disease: Potential mechanisms for an association

FS Giorgi, LF Saccaro, CL Busceti, F Biagioni… - Brain Research …, 2020 - Elsevier
Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence
of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for …