Polyploidization, the addition of a complete set of chromosomes to the genome, represents
one of the most dramatic mutations known to occur. Nevertheless, polyploidy is well …

In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …

Sometimes mutations in two genes produce a phenotype that is surprising in light of each
mutation's individual effects. This phenomenon, which defines genetic interaction, can …

Asymmetric postmating isolation, where reciprocal interspecific crosses produce different
levels of fertilization success or hybrid sterility/inviability, is very common. Darwin …

Systematic genetic interaction studies have illuminated many cellular processes. Here we
quantitatively examine genetic interactions among 26 Saccharomyces cerevisiae genes …

Despite many years of theoretical and experimental work, the explanation for why sex is so
common as a reproductive strategy continues to resist understanding. Recent empirical work …

Data from several thousand knockout mutations in yeast (Saccharomyces cerevisiae) were
used to estimate the distribution of dominance coefficients. We propose a new unbiased …

Combinatorial CRISPR-Cas screens have advanced the mapping of genetic interactions,
but their experimental scale limits the number of targetable gene combinations. Here, we …

Why are most genes dispensable? The impact of gene deletions may depend on the
environment (plasticity), the presence of compensatory mechanisms (mutational …

Deleterious mutations tend to be recessive. Several theories, notably those of Fisher (based
on selection) and Wright (based on metabolism), have been put forward to explain this …