Ubiquitin is the founding member of a family of structurally conserved proteins that regulate
a host of processes in eukaryotic cells. Ubiquitin and its relatives carry out their functions …

The 76-residue protein ubiquitin exists within eukaryotic cells both as a monomer and in the
form of isopeptide-linked polymers called polyubiquitin chains. In two well-described cases …

The role of protein ubiquitylation in the control of diverse cellular pathways has recently
gained widespread attention. Ubiquitylation not only directs the targeted destruction of …

E3 ubiquitin ligases have emerged as key molecular regulators of immune cell function.
Three families of proteins with ubiquitin ligase activity have been described (the HECT …

Patients affected by Sjögren's syndrome and systemic lupus erythematosus (SLE) carry
autoantibodies to an intracellular protein denoted Ro52. Although the serologic presence of …

The adapter protein TRAF6 is critical for mediating signal transduction from members of the
IL-1R/TLR and TNFR superfamilies. The TRAF6 RING finger domain functions as an …

A conserved catalytic residue in the ubiquitin‐conjugating enzyme family | The EMBO Journal
All EMBO Press journals Open Access as of 1 January 2024 - read the FAQs logo embp press …

Ubiquitin-like proteins (UBLs) such as NEDD8 are transferred to their targets by distinct,
parallel, multienzyme cascades that involve the sequential action of E1, E2 and E3 …

Abstract Development of effective cancer therapeutic strategies relies on our ability to
interfere with cellular processes that are dysregulated in tumors. Given the essential role of …

Ubiquitylated proteins are directed into a large number of different cellular pathways through
interactions with effector proteins that contain conserved ubiquitin binding motifs. Here, we …