Appendage regeneration in vertebrates: what makes this possible?
V Daponte, P Tylzanowski, A Forlino - Cells, 2021 - mdpi.com
The ability to regenerate amputated or injured tissues and organs is a fascinating property
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …
shared by several invertebrates and, interestingly, some vertebrates. The mechanism of …
Appendage regeneration in anamniotes utilizes genes active during larval‐metamorphic stages that have been lost or altered in amniotes: the case for studying lizard …
L Alibardi - Journal of morphology, 2020 - Wiley Online Library
This review elaborates the idea that organ regeneration derives from specific evolutionary
histories of vertebrates. Regenerative ability depends on genomic regulation of genes …
histories of vertebrates. Regenerative ability depends on genomic regulation of genes …
Transcriptome analysis of the regenerating tail vs. the scarring limb in lizard reveals pathways leading to successful vs. unsuccessful organ regeneration in amniotes
Background: Lizards are amniotes regenerating the tail but not the limb, and no information
on their different gene expression is available. Results: Transcriptomes of regenerating tail …
on their different gene expression is available. Results: Transcriptomes of regenerating tail …
An emerging frontier in intercellular communication: extracellular vesicles in regeneration
PN Avalos, DJ Forsthoefel - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Regeneration requires cellular proliferation, differentiation, and other processes that are
regulated by secreted cues originating from cells in the local environment. Recent studies …
regulated by secreted cues originating from cells in the local environment. Recent studies …
Biological and molecular differences between tail regeneration and limb scarring in lizard: an inspiring model addressing limb regeneration in amniotes
L Alibardi - Journal of Experimental Zoology Part B: Molecular …, 2017 - Wiley Online Library
Tissue regeneration in lizards represents a unique model of regeneration and scarring in
amniotes. The tail and limb contain putative stem cells but also dedifferentiating cells …
amniotes. The tail and limb contain putative stem cells but also dedifferentiating cells …
Downregulation of lizard immuno-genes in the regenerating tail and myogenes in the scarring limb suggests that tail regeneration occurs in an immuno-privileged …
Amputated tails of lizards regenerate while limbs form scars which histological structure is
very different from the original organs. Lizards provide useful information for regenerative …
very different from the original organs. Lizards provide useful information for regenerative …
Genome-wide characterization of the TGF-β gene family and their expression in different tissues during tail regeneration in the Schlegel's Japanese gecko Gekko …
Q Liu, RM Zhao, DY Wang, P Li, YF Qu, X Ji - International Journal of …, 2024 - Elsevier
The transforming growth factor-β (TGF-β) gene family is unique to animals and is involved in
various important processes including tissue regeneration. Here, we identified 52 TGF-β …
various important processes including tissue regeneration. Here, we identified 52 TGF-β …
Limb regeneration in humans: Dream or reality?
L Alibardi - Annals of Anatomy-Anatomischer Anzeiger, 2018 - Elsevier
Appendage regeneration occurs by a sequence of events resembling those that take place
during development in the embryo. This requires embryonic conditions such as hydration …
during development in the embryo. This requires embryonic conditions such as hydration …
Regeneration of the tail in lizards appears regulated by a balanced expression of oncogenes and tumor suppressors
L Alibardi - Annals of Anatomy-Anatomischer Anzeiger, 2022 - Elsevier
Background Tail regeneration in lizards is the only case of large multi-tissue organ
regeneration in amniotes. Methods The present Review summarizes numerous …
regeneration in amniotes. Methods The present Review summarizes numerous …
The regenerating tail blastema of lizards as a model to study organ regeneration and tumor growth regulation in amniotes
L Alibardi - The Anatomical Record, 2019 - Wiley Online Library
Tail regeneration in lizards is a unique case of organ regeneration among amniotes. The
Review summarizes past and recent studies indicating that tail regeneration utilizes …
Review summarizes past and recent studies indicating that tail regeneration utilizes …