Homeostasis of energy is regulated by genetic factors, food intake, and energy expenditure.
When energy input is greater than expenditure, the balance is positive, which can lead to …

Abstract Exposure to Adverse Childhood Experiences (ACEs) is associated with a host of
harmful outcomes, including increased risk for cancer. A scoping review was conducted to …

Early life adversity remains a significant risk factor for the development of a host of negative
behavioural and pathological outcomes in adulthood long after the stressor is over. Recent …

Abstract The Developmental Origins of Health and Disease (DOHaD) hypothesizes that
environmental insults during childhood programs the individual to develop chronic disease …

Context: Irisin is a recently identified myokine affecting metabolic and glucose homeostasis.
However, the role of irisin in obesity and its metabolic consequences are controversial, and …

Alterations in the brain-gut system have been implicated in various disease states, but little
is known about how early-life adversity (ELA) impacts development and adult health as …

Introduction Exogenous administration of recombinant irisin improves glucose metabolism.
However, the association of endogenous circulating (plasma/serum) irisin with insulin …

The physiological response to a psychological stressor broadly impacts energy metabolism.
Inversely, changes in energy availability affect the physiological response to the stressor in …

Problem: Incorporating biomarkers of chronic stress into pediatric research studies may help
to explicate the links between exposure to adversity and lifelong health, but there are …

Objective: To determine the impact of childhood adversity and current (adulthood) resilience
on mental and physical health and markers of metabolic function among adults with …