The two β-arrestins, β-arrestin-1 and-2 (systematic names: arrestin-2 and-3, respectively),
are multifunctional intracellular proteins that regulate the activity of a very large number of …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

G protein-coupled receptor (GPCR)-biased agonism, selective activation of certain signaling
pathways relative to others, is thought to be directed by differential GPCR phosphorylation" …

Biased G protein–coupled receptor (GPCR) ligands, which preferentially activate G protein
or β-arrestin signaling pathways, are leading to the development of drugs with superior …

The architecture of eukaryotic cells is defined by extensive membrane-delimited
compartments, which entails separate metabolic processes that would otherwise interfere …

Cholinergic regulation of dopamine (DA) signaling has significant implications for numerous
disorders, including schizophrenia, substance use disorders, and mood-related disorders …

The quaternary organization of rhodopsin-like G protein-coupled receptors in native tissues
is unknown. To address this we generated mice in which the M1 muscarinic acetylcholine …

Docetaxel is the most commonly used chemotherapy for advanced prostate cancer (PC),
including castration-resistant disease (CRPC), but the eventual development of docetaxel …

G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a
critical role in nervous system function by transmitting signals between cells and their …

Alzheimer's disease (AD) is spreading its root disproportionately among the worldwide
population. Many genes have been identified as the hallmarks of AD. Based upon the …