The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Evidence has increasingly shown that the lungs are a major site of immune regulation. A
robust and highly regulated immune response in the lung protects the host from pathogen …

Only a handful of the more than 100,000 fungal species on our planet cause disease in
humans, yet the number of life-threatening fungal infections in patients has recently …

Pathogenic fungi cause a wide range of syndromes in immune-competent and immune-
compromised individuals, with life-threatening disease primarily seen in humans with …

Summary The interleukin-17 (IL-17) family of cytokines phylogenetically predates the
evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the Th17 cell …

The global increase in fungal disease burden, the emergence of novel pathogenic fungi,
and the lack of fungal vaccines have focused intense interest in elucidating immune defense …

Vaccine immunity to the endemic mycoses of North America requires Th17 cells, but the
pattern recognition receptors and signaling pathways that drive these protective responses …

Coccidioidomycosis is a human fungal disease cause by inhalation of aerosol spores
produced by Coccidioides posadasii or Coccidioides immitis. This disease is a common …

In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

Fungi represent emerging infectious threats to human populations worldwide. Mice and
other laboratory animals have proved invaluable in modeling clinical syndromes associated …