Genetics of sinoatrial node function and heart rate disorders
LE van der Maarel, AV Postma… - Disease models & …, 2023 - journals.biologists.com
The sinoatrial node (SAN) is the primary pacemaker of the mammalian heart, initiating its
electrical activation and ensuring that the heart's functional cardiac output meets …
electrical activation and ensuring that the heart's functional cardiac output meets …
Genetic testing in early-onset atrial fibrillation
Atrial fibrillation (AF) is a globally prevalent cardiac arrhythmia with significant genetic
underpinnings, as highlighted by recent large-scale genetic studies. A prominent clinical …
underpinnings, as highlighted by recent large-scale genetic studies. A prominent clinical …
LMNA cardiomyopathy: important considerations for the heart failure clinician
Background A diagnosis of Lamin proteins A and C cardiomyopathy (LMNA-CM) not only
impacts disease prognosis, but also leads to specific guideline-recommended treatment …
impacts disease prognosis, but also leads to specific guideline-recommended treatment …
Interatrial block as a first clinical presentation of atrial cardiomyopathy related to a novel LMNA variant: a case report
M Iavarone, S Covino, R Petillo… - European Heart Journal …, 2023 - academic.oup.com
Background Interatrial block (IAB) is a conduction delay in Bachmann's bundle with a well-
described association with structural heart disease, supraventricular arrhythmias, and …
described association with structural heart disease, supraventricular arrhythmias, and …
[HTML][HTML] Genetics and Pharmacogenetics of Atrial Fibrillation: A Mechanistic Perspective
The heritability of atrial fibrillation (AF) is well established. Over the last decade genetic
architecture of AF has been unraveled by genome-wide association studies and family …
architecture of AF has been unraveled by genome-wide association studies and family …
Atrial standstill associated with lamin A/C mutation: A case report
Y Zhang, Y Zhang, M Ren, M Xue… - … Open Medical Case …, 2023 - journals.sagepub.com
The case report shares evidence for a better understanding of atrial standstill. This being a
rare arrhythmogenic condition. This is a 46-year-old woman presented with multiple sites of …
rare arrhythmogenic condition. This is a 46-year-old woman presented with multiple sites of …
Structural and functional abnormalities of left-sided cardiac chambers in Barlow's disease without significant mitral regurgitation
MC Meucci, V Mantegazza, HW Wu… - European Heart …, 2024 - academic.oup.com
Aims This study aims to explore the presence of left ventricular (LV) and left atrial (LA)
morphological and functional abnormalities in patients with Barlow's disease (BD) without …
morphological and functional abnormalities in patients with Barlow's disease (BD) without …
A silent interweaving: interatrial block and laminopathy
VA Rossi, AM Saguner - European Heart Journal-Case Reports, 2023 - academic.oup.com
Variants in the lamin (LMNA) gene, responsible for encoding nuclear Lamin proteins A and
C, constitute a frequent cause of familial dilated cardiomyopathy (DCM) after titin (TTN) …
C, constitute a frequent cause of familial dilated cardiomyopathy (DCM) after titin (TTN) …
Pregnancy and progression of cardiac disease in genetic cardiomyopathies
AI Castrini - 2024 - duo.uio.no
Genetic cardiomyopathies are hereditary cardiac diseases often diagnosed in young
patients and are characterized by live-threatening arrhythmias and heart failure. Among …
patients and are characterized by live-threatening arrhythmias and heart failure. Among …
Clinical Impact of Pathogenic and Potentially Pathogenic Rare Variants in Ethnic Minorities with Atrial Fibrillation
MC Hill, B Chalazan, S Sandhu, JH Arnold, P Boxley… - papers.ssrn.com
Background: Rare arrhythmia and cardiomyopathy gene variants have been associated with
all-cause mortality among individuals of European ancestry with atrial fibrillation (AF). The …
all-cause mortality among individuals of European ancestry with atrial fibrillation (AF). The …