Recent evidence suggests that Alzheimer's disease (AD) is closely linked with insulin
resistance, as seen in type 2 diabetes mellitus (T2DM). Insulin signaling is impaired in AD …

It has been proposed that a “common core” of pathologic pathways exists for the large family
of amyloid-associated neurodegenerations, including Alzheimer's, Parkinson's, type II …

Many neurodegenerative diseases are associated with the self-assembly of peptides and
proteins into fibrillar aggregates. Soluble misfolded oligomers formed during the …

Over the last few decades, the global prevalence of neurodevelopmental and
neurodegenerative illnesses has risen rapidly. Although the aetiology remains unclear …

Neurodegenerative diseases (NDs) represent an unsolved problem to date with an
everincreasing population incidence. Particularly, Alzheimer's disease (AD) is the most …

Peptide oligomerization dynamics affects peptide structure, activity, and pharmacodynamic
properties. The thrombin C-terminal peptide, TCP-25 (GKYGFYTHVFRLKKWIQKVIDQFGE) …

Neuronal death could be responsible for the cognitive impairments found in astronauts
exposed to spaceflight, highlighting the need to identify potential countermeasures to ensure …

Human calcitonin (hCT) is a 32‐residue peptide that aggregates to form amyloid fibrils under
appropriate conditions. In this study, we investigated the effect of the intramolecular disulfide …

Recent study suggests that protofibril-formation of amyloidogenic proteins (APs) might be
involved in evolvability, an epigenetic inheritance of multiple stresses, in various biological …

Salmon calcitonin is a good model for studying amyloid behavior and neurotoxicity. Its slow
aggregation rate allows the purification of low molecular weight prefibrillar oligomers, which …