Lung cancer is the leading cause of cancer-related death across the world. Unlike lung
adenocarcinoma, patients with lung squamous cell carcinoma (LSCC) have not benefitted …

p53 is an important tumor suppressor gene, which is stimulated by cellular stress like
ionizing radiation, hypoxia, carcinogens, and oxidative stress. Upon activation, p53 leads to …

Epithelial tissue homeostasis is closely associated with the self-renewal and differentiation
behaviors of epithelial stem cells (ESCs). p63, a well-known marker of ESCs, is an …

Our understanding of how stem cells are regulated to maintain appropriate tissue size and
architecture is incomplete. We show that Yap (Yes-associated protein 1) is required for the …

Emerging evidence suggests that cancer is populated and maintained by tumour-initiating
cells (TICs) with stem-like properties similar to those of adult tissue stem cells. Despite …

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial−
myoepithelial differentiation, whose genetic underpinning is largely unknown. Here we show …

ABSTRACT p63 (also known as TP63) is a transcription factor of the p53 family, along with
p73. Multiple isoforms of p63 have been discovered and these have diverse functions …

Chromatin conformation constitutes a fundamental level of eukaryotic genome regulation.
However, our ability to examine its biological function and role in disease is limited by the …

The YAP1/Hippo and p53 pathways are critical protectors of genome integrity in response to
DNA damage. Together, these pathways secure cellular adaptation and maintain overall …

ABSTRACT TLR3 belong to the Toll-like receptors family, it is mainly expressed on immune
cells where it senses pathogen-associated molecular patterns and initiates innate immune …