Adoptive cell therapy has emerged as a powerful treatment for advanced cancers resistant
to conventional agents. Most notable are the remarkable responses seen in patients …

Mesenchymal stem cells (MSCs) are currently being widely investigated both in the lab and
in clinical trials for multiple disease states. The differentiation, trophic, and …

Stem cell therapies are limited by poor cell survival and engraftment. A hurdle to the use of
materials for cell delivery is the lack of understanding of material properties that govern …

Endodontic management of immature permanent teeth with necrotic pulps is both a clinical
problem for dental practitioners and a public health care problem. Although it is feasible to …

ABSTRACT Human Mesenchymal Stem Cells, hMSCs, were first named over 25 years ago
with the “stem cell” nomenclature derived from the fact that we and others could cause these …

The endodontic management of permanent immature teeth is fraught with challenges.
Although treatment modalities for vital pulp therapy in these teeth provide long-term …

Gene therapy protocols require robust and long-term gene expression. For two decades,
retrovirus family vectors have offered several attractive properties as stable gene-delivery …

Decellularized scaffolds are promising clinically translational biomaterials that can be
applied to direct cell responses and promote tissue regeneration. Bioscaffolds derived from …

Allogeneic mesenchymal stromal cells (MSCs) are a safe treatment option for many
disorders of the immune system. However, clinical trials using MSCs have shown …

As treatments for diseases throughout the body progress, treatment for many brain diseases
has been at a standstill due to difficulties in drug delivery. While new drugs are being …