Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
[HTML][HTML] Magnesium in man: implications for health and disease
JHF De Baaij, JGJ Hoenderop… - Physiological …, 2015 - journals.physiology.org
Abstract Magnesium (Mg 2+) is an essential ion to the human body, playing an instrumental
role in supporting and sustaining health and life. As the second most abundant intracellular …
role in supporting and sustaining health and life. As the second most abundant intracellular …
[HTML][HTML] Synaptic proximity enables NMDAR signalling to promote brain metastasis
Metastasis—the disseminated growth of tumours in distant organs—underlies cancer
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …
mortality. Breast-to-brain metastasis (B2BM) is a common and disruptive form of cancer and …
Molecular mechanisms of glutamate toxicity in Parkinson's disease
J Wang, F Wang, D Mai, S Qu - Frontiers in neuroscience, 2020 - frontiersin.org
Parkinson's disease (PD) is a common neurodegenerative disease, the pathological
features of which include the presence of Lewy bodies and the neurodegeneration of …
features of which include the presence of Lewy bodies and the neurodegeneration of …
Chronic glutamate toxicity in neurodegenerative diseases—what is the evidence?
J Lewerenz, P Maher - Frontiers in neuroscience, 2015 - frontiersin.org
Together with aspartate, glutamate is the major excitatory neurotransmitter in the brain.
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Glutamate binds and activates both ligand-gated ion channels (ionotropic glutamate …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
NMDA receptors: linking physiological output to biophysical operation
GJ Iacobucci, GK Popescu - Nature Reviews Neuroscience, 2017 - nature.com
NMDA receptors are preeminent neurotransmitter-gated channels in the CNS, which
respond to glutamate in a manner that integrates multiple external and internal cues. They …
respond to glutamate in a manner that integrates multiple external and internal cues. They …
Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses
Neurotransmitter is released synchronously and asynchronously following an action
potential. Our recent study indicates that the release sites of these two phases are …
potential. Our recent study indicates that the release sites of these two phases are …
Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses
J Goncalves, TM Bartol, C Camus… - Proceedings of the …, 2020 - National Acad Sciences
The nanoscale co-organization of neurotransmitter receptors facing presynaptic release
sites is a fundamental determinant of their coactivation and of synaptic physiology. At …
sites is a fundamental determinant of their coactivation and of synaptic physiology. At …
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
TA Blanpied, RJ Clarke, JW Johnson - Journal of Neuroscience, 2005 - Soc Neuroscience
The channel of NMDA receptors is blocked by a wide variety of drugs. NMDA receptor
channel blockers include drugs of abuse that induce psychotic behavior, such as …
channel blockers include drugs of abuse that induce psychotic behavior, such as …