The molecular basis and disease relevance of non-homologous DNA end joining
B Zhao, E Rothenberg, DA Ramsden… - … Reviews Molecular Cell …, 2020 - nature.com
Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …
Structural insights into the evolution of the RAG recombinase
Adaptive immunity in jawed vertebrates relies on the assembly of antigen receptor genes by
the recombination activating gene 1 (RAG1)–RAG2 (collectively RAG) recombinase in a …
the recombination activating gene 1 (RAG1)–RAG2 (collectively RAG) recombinase in a …
CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks
Cryo-electron microscopy (cryo-EM) single-particle analysis has proven powerful in
determining the structures of rigid macromolecules. However, many imaged protein …
determining the structures of rigid macromolecules. However, many imaged protein …
Design powerful predictor for mRNA subcellular location prediction in Homo sapiens
Messenger RNAs (mRNAs) shoulder special responsibilities that transmit genetic code from
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
DNA to discrete locations in the cytoplasm. The locating process of mRNA might provide …
The recent advances in non-homologous end-joining through the lens of lymphocyte development
XS Wang, BJ Lee, S Zha - DNA repair, 2020 - Elsevier
Lymphocyte development requires ordered assembly and subsequent modifications of the
antigen receptor genes through V (D) J recombination and Immunoglobulin class switch …
antigen receptor genes through V (D) J recombination and Immunoglobulin class switch …
[HTML][HTML] How DNA loop extrusion mediated by cohesin enables V (D) J recombination
JM Peters - Current opinion in cell biology, 2021 - Elsevier
Abstract 'Structural maintenance of chromosomes'(SMC) complexes are required for the
folding of genomic DNA into loops. Theoretical considerations and single-molecule …
folding of genomic DNA into loops. Theoretical considerations and single-molecule …
RAG2 abolishes RAG1 aggregation to facilitate V (D) J recombination
RAG1 and RAG2 form a tetramer nuclease to initiate V (D) J recombination in developing T
and B lymphocytes. The RAG1 protein evolves from a transposon ancestor and possesses …
and B lymphocytes. The RAG1 protein evolves from a transposon ancestor and possesses …
Analysis of IGH allele content in a sample group of rheumatoid arthritis patients demonstrates unrevealed population heterogeneity
U Hardt, MM Corcoran, S Narang… - Frontiers in …, 2023 - frontiersin.org
Immunoglobulin heavy chain (IGH) germline gene variations influence the B cell receptor
repertoire, with resulting biological consequences such as shaping our response to …
repertoire, with resulting biological consequences such as shaping our response to …
Cutting antiparallel DNA strands in a single active site
A single enzyme active site that catalyzes multiple reactions is a well-established
biochemical theme, but how one nuclease site cleaves both DNA strands of a double helix …
biochemical theme, but how one nuclease site cleaves both DNA strands of a double helix …
Molecular mechanisms of DNA sequence selectivity in V (D) J recombination
W Hoolehan, JC Harris, KK Rodgers - ACS omega, 2023 - ACS Publications
Antigen receptor (AgR) diversity is central to the ability of adaptive immunity in jawed
vertebrates to protect against pathogenic agents. The production of highly diverse AgR …
vertebrates to protect against pathogenic agents. The production of highly diverse AgR …