The sodium and potassium gradients across the plasma membrane are used by animal cells
for numerous processes, and the range of demands requires that the responsible ion pump …

Genetic research has shown that mutations that modify the protein-coding sequence of
ATP1A3, the gene encoding the α 3 subunit of Na+/K+-ATPase, cause both rapid-onset …

Parkinson's disease (PD) is currently the second most common neurodegenerative disease,
being characterized by motor and non-motor symptoms. The therapeutic options available …

During neuronal activity in the brain, extracellular K+ rises and is subsequently removed to
prevent a widespread depolarization. One of the key players in regulating extracellular K+ is …

Neurodegeneration correlates with Alzheimer's disease (AD) symptoms, but the molecular
identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to …

Background Alternating hemiplegia of childhood (AHC) is a rare neurological disorder
characterised by early-onset episodes of hemiplegia, dystonia, various paroxysmal …

Abstract The Na+, K+-ATPase, or sodium pump, is well known for its role in ion transport
across the plasma membrane of animal cells. It carries out the transport of Na+ ions out of …

Background ATP1A3 mutations have now been recognized in infants and children
presenting with a diverse group of neurological phenotypes, including Rapid-onset Dystonia …

Summary Objective Mutations of ATP 1A3 have been associated with rapid onset dystonia‐
parkinsonism and more recently with alternating hemiplegia of childhood. Here we report …

The Na+/K+ ATPases are Sodium-Potassium exchanging pumps, with a heteromeric α-β-γ
protein complex. The α3 isoform is required as a rescue pump, after repeated action …