Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised …
Background GLP-1 receptor agonists reduce major adverse cardiovascular events (MACE)
in patients with type 2 diabetes. However, uncertainty regarding kidney outcomes persists …
in patients with type 2 diabetes. However, uncertainty regarding kidney outcomes persists …
Treatment of type 2 diabetes: challenges, hopes, and anticipated successes
MA Nauck, J Wefers, JJ Meier - The lancet Diabetes & endocrinology, 2021 - thelancet.com
Despite the successful development of new therapies for the treatment of type 2 diabetes,
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
such as glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose …
Type 2 diabetes
Summary 415 million people live with diabetes worldwide, and an estimated 193 million
people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients …
people have undiagnosed diabetes. Type 2 diabetes accounts for more than 90% of patients …
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
5′-Adenosine monophosphate–activated protein kinase (AMPK) is a master regulator of
energy homeostasis in eukaryotes. Despite three decades of investigation, the biological …
energy homeostasis in eukaryotes. Despite three decades of investigation, the biological …
Sugar-lowering drugs for type 2 diabetes mellitus and metabolic syndrome—Review of classical and new compounds: Part-I
R Vieira, SB Souto, E Sánchez-López… - Pharmaceuticals, 2019 - mdpi.com
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia
together with disturbances in the metabolism of carbohydrates, proteins and fat, which in …
together with disturbances in the metabolism of carbohydrates, proteins and fat, which in …
Nuclear receptors: recent drug discovery for cancer therapies
L Zhao, S Zhou, JÅ Gustafsson - Endocrine reviews, 2019 - academic.oup.com
Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …
Prevalence and in-hospital outcomes of diabetes among patients with acute coronary syndrome in China: findings from the Improving Care for Cardiovascular …
M Zhou, J Liu, Y Hao, J Liu, Y Huo, SC Smith… - Cardiovascular …, 2018 - Springer
Background Guidelines have classified patients with acute coronary syndrome (ACS) and
diabetes as a special population, with specific sections presented for the management of …
diabetes as a special population, with specific sections presented for the management of …
An update on the molecular and cellular basis of pharmacotherapy in type 2 diabetes mellitus
Diabetes mellitus (DM) is a chronic illness with an increasing global prevalence. More than
537 million cases of diabetes were reported worldwide in 2021, and the number is steadily …
537 million cases of diabetes were reported worldwide in 2021, and the number is steadily …
Legume-derived bioactive peptides in type 2 diabetes: opportunities and challenges
K Hu, H Huang, H Li, Y Wei, C Yao - Nutrients, 2023 - mdpi.com
Diabetes mellitus is a complex disorder characterized by insufficient insulin production or
insulin resistance, which results in a lifelong dependence on glucose-lowering drugs for …
insulin resistance, which results in a lifelong dependence on glucose-lowering drugs for …
Peptides Derived from Soy and Lupin Protein as Dipeptidyl-Peptidase IV Inhibitors: In Vitro Biochemical Screening and in Silico Molecular Modeling Study
C Lammi, C Zanoni, A Arnoldi… - Journal of Agricultural and …, 2016 - ACS Publications
Dipeptidyl peptidase IV (DPP-IV) is a new molecular target correlated with the development
of type 2 diabetes. Literature describes the identification of some inhibitory peptides from the …
of type 2 diabetes. Literature describes the identification of some inhibitory peptides from the …