Abstract γ-aminobutyric acid type B (GABA B) receptors are broadly expressed in the
nervous system and play an important role in neuronal excitability. GABA B receptors are G …

Opioids are among the most effective analgesics available and are the first choice in the
treatment of acute severe pain. However, partial efficacy, a tendency to produce tolerance …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …

G protein-dependent signaling pathways control the activity of excitable cells of the nervous
system and heart, and are the targets of neurotransmitters, clinically relevant drugs, and …

G protein-gated inwardly rectifying K+ (GIRK/Kir3) channels exert a critical inhibitory
influence on neurons. Neuronal GIRK channels mediate the G protein-dependent …

Opioids are among the most effective drugs to treat severe pain. They produce their
analgesic actions by specifically activating opioid receptors located along the pain …

G protein-gated inwardly rectifying K+(GIRK/K ir 3) channels are critical to brain function.
They hyperpolarize neurons in response to activation of different G protein-coupled …

G protein‐gated inwardly‐rectifying K+ (GIRK/family 3 of inwardly‐rectifying K+) channels
are coupled to neurotransmitter action and can play important roles in modulating neuronal …

GABAB receptors are G-protein-coupled receptors that mediate inhibitory synaptic actions
through a series of downstream target proteins. It is increasingly appreciated that the GABAB …