Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …

Neutrophil recruitment is an important early step in controlling tissue infections or injury.
Here, we report that this influx depends on both tissue-resident mast cells and …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Mast cells are haematopoietic cells that arise from pluripotent precursors of the bone
marrow. They play immunomodulatory roles in both health and disease. When appropriately …

The most abundant prestored enzyme of human mast cell secretory granules is the serine-
protease tryptase. In humans, there are four tryptase isoforms, but only two of them, namely …

Mast cells are versatile effector cells of the immune system, contributing to both innate and
adaptive immunity toward pathogens but also having profound detrimental activities in the …

Mast cell activation disease comprises disorders characterized by accumulation of
genetically altered mast cells and/or abnormal release of these cells' mediators, affecting …

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common and
devastating clinical disorders with high mortality and no specific therapy …

The discovery of MRGPRX2 marks an important change in MC biology, explaining non‐IgE‐
mediated clinical phenomena relying on MCs. As receptor for multiple drugs, MRGPRX2 is …