Intensiometric genetically encoded biosensors, based on allosteric modulation of the
fluorescence of a single fluorescent protein, are powerful tools for enabling imaging of …

Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces
nitric-oxide-and natriuretic-peptide-coupled signalling, stimulating phosphorylation changes …

NADH is a key metabolic cofactor whose sensitive and specific detection in the cytosol of
live cells has been difficult. We constructed a fluorescent biosensor of the cytosolic NADH …

Biomass-derived carbon dots (CDs) are promising nanotools for agricultural applications
and function as a reactive oxygen species (ROS) scavenger to alleviate plant oxidative …

As a chemical transmitter in the mammalian central nervous system, nitric oxide (NO) is still
thought a bit of an oddity, yet this role extends back to the beginnings of the evolution of the …

Fluorescence and bioluminescence resonance energy transfer (FRET and BRET)
techniques allow the sensitive monitoring of distances between two labels at the nanometer …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

Abstract cAMP is a key second messenger that regulates diverse cellular functions including
neural plasticity. However, the spatiotemporal dynamics of intracellular cAMP in intact …

Nitric oxide (NO•; nitrogen monoxide) is known to be a critical regulator of cell and tissue
function through mechanisms that utilize its unique physicochemical properties as a small …