Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Nicotinamide adenine dinucleotide (NAD+) is a co-substrate for several enzymes, including
the sirtuin family of NAD+-dependent protein deacylases. Beneficial effects of increased …

A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

NAD+ is an important cofactor regulating metabolic homeostasis and a rate-limiting
substrate for sirtuin deacylases. We show that NAD+ levels are reduced in aged mice and …

This study was aimed at investigating the hypoglycemic and hypolipidemic effects of a
polysaccharide (RTFP) isolated from Rosa roxburghii Tratt fruit on type-2 diabetic db/db …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Background and Aims Oxaliplatin (OXA) is one of the most common chemotherapeutics in
advanced hepatocellular carcinoma (HCC), the resistance of which poses a big challenge …

Culinary herbs and spices are widely used as a traditional medicine in the treatment of
diabetes and its complications, and there are several scientific studies in the literature …