[HTML][HTML] Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials

M Pfau, JK Jolly, Z Wu, J Denniss, EM Lad… - Progress in Retinal and …, 2021 - Elsevier
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …

Progression of photoreceptor degeneration in geographic atrophy secondary to age-related macular degeneration

M Pfau, L von der Emde, L de Sisternes… - JAMA …, 2020 - jamanetwork.com
Importance Sensitive outcome measures for disease progression are needed for treatment
trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) …

Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy

M Pfau, S Schmitz-Valckenberg, R Ribeiro, R Safaei… - Scientific Reports, 2022 - nature.com
Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …

[HTML][HTML] Photoreceptor degeneration in ABCA4-associated retinopathy and its genetic correlates

M Pfau, CA Cukras, LA Huryn, WM Zein, E Ullah… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Outcome measures sensitive to disease progression are needed for ATP-
binding cassette, sub-family A, member 4–associated (ABCA4-associated) retinopathy. We …

Quantification of geographic atrophy using spectral domain OCT in age-related macular degeneration

SC Cleland, SM Konda, RP Danis, Y Huang… - Ophthalmology …, 2021 - Elsevier
Purpose To compare geographic atrophy (GA) area and enlargement rate measured with
spectral domain OCT (SD-OCT) with fundus autofluorescence (FAF), color fundus …

Cones in ageing and harsh environments: the neural economy hypothesis

AE Elsner, JA Papay, KD Johnston… - Ophthalmic and …, 2020 - Wiley Online Library
Purpose Cones are at great risk in a wide variety of retinal diseases, especially when there
is a harsh microenvironment and retinal pigment epithelium is damaged. We provide …

[HTML][HTML] Microperimetry Characteristics of Regions With a Truly Nonresponding Location: Implications for Atrophic Age-Related Macular Degeneration

Z Wu, M Pfau, M Fleckenstein… - … Ophthalmology & Visual …, 2024 - tvst.arvojournals.org
Purpose: To understand the microperimetry response characteristics of regions with a truly
nonresponding location, which will be useful when considering criteria for end-stage …

[HTML][HTML] Repeatability of Microperimetry in areas of RPE and Photoreceptor loss in Geographic Atrophy supported by AI-based OCT biomarker quantification

LM Coulibaly, K Birner, A Zarghami… - American Journal of …, 2024 - Elsevier
Purpose Growing interest in microperimetry (MP) or fundus-controlled perimetry (FCP) as
targeted psychometric testing method in geographic atrophy (GA) is warranted due to the …

Evaluation of cone-and rod-mediated parameters in dark adaptation testing as outcome measures in age-related macular degeneration

K Hess, T de Silva, P Grisso, H Wiley… - Ophthalmology …, 2022 - Elsevier
Purpose To investigate the suitability of 6 rod-or cone-mediated dark adaptation (DA)
parameters as outcome measures for clinical trials in age-related macular degeneration …

Visual Sensitivity Loss in Geographic Atrophy: Structure–Function Evaluation Using Defect-Mapping Microperimetry

Z Wu, X Hadoux, M Jannaud, EK Glover… - … & Visual Science, 2024 - iovs.arvojournals.org
Purpose: To examine the structure–function relationship in eyes with geographic atrophy
(GA) using defect-mapping microperimetry, a testing strategy optimized to quantify the …