Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phosphoinositides are membrane-bound signalling molecules that regulate cell proliferation
and survival, cytoskeletal reorganization and vesicular trafficking by recruiting effector …

The precise regulation of phosphoinositide lipids in cellular membranes is crucial for cellular
survival and function. Inositol 5-phosphatases have been implicated in a variety of disorders …

Phosphoinositides are essential signaling molecules linked to a diverse array of cellular
processes in eukaryotic cells. The metabolic interconversions of these phospholipids are …

Phosphoinositide phosphatases comprise several large enzyme families with over 35
mammalian enzymes identified to date that degrade many phosphoinositide signals. Growth …

Phosphoinositides (PIs) are a group of key signaling and structural lipid molecules involved
in a myriad of cellular processes. PI phosphatases, together with PI kinases, are responsible …

The soaring incidence of type 2 diabetes has created pressure for new pharmaceutical
strategies to treat this devastating disease. With much of the focus on overcoming insulin …

We describe rapid massive endocytosis (MEND) of> 50% of the plasmalemma in baby
hamster kidney (BHK) and HEK293 cells in response to large Ca transients. Constitutively …

Phosphoinositide signalling molecules interact with a plethora of effector proteins to regulate
cell proliferation and survival, vesicular trafficking, metabolism, actin dynamics and many …

Phosphoinositol phosphatases are important regulators of signaling pathways relevant to
both diabetes and cancer. A 3′-phosphoinositol phosphatase, phosphatase homologous to …