Fusogenic reoviruses and their fusion-associated small transmembrane (FAST) proteins
R Duncan - Annual review of virology, 2019 - annualreviews.org
With no limiting membrane surrounding virions, nonenveloped viruses have no need for
membrane fusion to gain access to intracellular replication compartments. Consequently …
membrane fusion to gain access to intracellular replication compartments. Consequently …
Reovirus FAST proteins: virus-encoded cellular fusogens
M Ciechonska, R Duncan - Trends in microbiology, 2014 - cell.com
Reovirus fusion-associated small transmembrane (FAST) proteins are the only known
nonenveloped virus fusogens and are dedicated to inducing cell-to-cell, not virus–cell …
nonenveloped virus fusogens and are dedicated to inducing cell-to-cell, not virus–cell …
Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons
Abstract Synaptotagmin 7 (SYT7) has emerged as a key regulator of presynaptic function,
but its localization and precise role in the synaptic vesicle cycle remain the subject of …
but its localization and precise role in the synaptic vesicle cycle remain the subject of …
Molecular basis for synaptotagmin-1-associated neurodevelopmental disorder
Summary At neuronal synapses, synaptotagmin-1 (syt1) acts as a Ca 2+ sensor that
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
synchronizes neurotransmitter release with Ca 2+ influx during action potential firing …
Golgi compartmentation and identity
E Papanikou, BS Glick - Current opinion in cell biology, 2014 - Elsevier
Recent work supports the idea that cisternae of the Golgi apparatus can be assigned to
three classes, which correspond to discrete stages of cisternal maturation. Each stage has a …
three classes, which correspond to discrete stages of cisternal maturation. Each stage has a …
Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons
JD Vevea, ER Chapman - Elife, 2020 - elifesciences.org
The success of comparative cell biology for determining protein function relies on quality
disruption techniques. Long-lived proteins, in postmitotic cells, are particularly difficult to …
disruption techniques. Long-lived proteins, in postmitotic cells, are particularly difficult to …
Reovirus FAST protein enhances vesicular stomatitis virus oncolytic virotherapy in primary and metastatic tumor models
The reovirus fusion-associated small transmembrane (FAST) proteins are the smallest
known viral fusogens (∼ 100–150 amino acids) and efficiently induce cell-cell fusion and …
known viral fusogens (∼ 100–150 amino acids) and efficiently induce cell-cell fusion and …
Glycans function as a Golgi export signal to promote the constitutive exocytic trafficking
Most proteins in the secretory pathway are glycosylated. However, the role of glycans in
membrane trafficking is still unclear. Here, we discovered that transmembrane secretory …
membrane trafficking is still unclear. Here, we discovered that transmembrane secretory …
Protein folding and secretion: mechanistic insights advancing recombinant protein production in S. cerevisiae
CL Young, AS Robinson - Current opinion in biotechnology, 2014 - Elsevier
Highlights•Review highlights ER quality control, associated protein interactions, and
trafficking motifs.•Describes changes to the UPR and HSR and their impact on heterologous …
trafficking motifs.•Describes changes to the UPR and HSR and their impact on heterologous …
Conserved but not critical: Trafficking and function of NaV1.7 are independent of highly conserved polybasic motifs
Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral
voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they …
voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they …