Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations
Z Miklja, A Pasternak, S Stallard, T Nicolaides… - Neuro …, 2019 - academic.oup.com
As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in
pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve …
pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve …
[HTML][HTML] Clinical efficacy of ONC201 in H3K27M-mutant diffuse midline gliomas is driven by disruption of integrated metabolic and epigenetic pathways
Abstract Patients with H3K27M-mutant diffuse midline glioma (DMG) have no proven
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the …
Liquid biopsy for pediatric diffuse midline glioma: a review of circulating tumor DNA and cerebrospinal fluid tumor DNA
Diffuse midline glioma (DMG) is a highly malignant childhood tumor with an exceedingly
poor prognosis and limited treatment options. The majority of these tumors harbor somatic …
poor prognosis and limited treatment options. The majority of these tumors harbor somatic …
Electronic DNA analysis of CSF cell-free tumor DNA to quantify multi-gene molecular response in pediatric high-grade glioma
Purpose: Pediatric high-grade glioma (pHGG) diagnosis portends poor prognosis and
therapeutic monitoring remains difficult. Tumors release cell-free tumor DNA (cf-tDNA) into …
therapeutic monitoring remains difficult. Tumors release cell-free tumor DNA (cf-tDNA) into …
Droplet digital PCR-based detection of circulating tumor DNA from pediatric high grade and diffuse midline glioma patients
E Izquierdo, P Proszek, G Pericoli… - Neuro-oncology …, 2021 - academic.oup.com
Background The use of liquid biopsy is of potential high importance for children with high
grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are …
grade (HGG) and diffuse midline gliomas (DMG), particularly where surgical procedures are …
[HTML][HTML] Liquid biopsy in pediatric brain tumors
Malignant primary brain tumors are the most common cancer in children aged 0–14 years,
and are the most common cause of death among pediatric cancer patients. Compared to …
and are the most common cause of death among pediatric cancer patients. Compared to …
Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors
Background The use of next‐generation sequencing for fusion identification is being
increasingly applied and aids our understanding of tumor biology. Some fusions are …
increasingly applied and aids our understanding of tumor biology. Some fusions are …
[HTML][HTML] The clinical applications of liquid biopsies in pediatric brain tumors: a systematic literature review
L Greuter, N Frank, R Guzman, J Soleman - Cancers, 2022 - mdpi.com
Simple Summary Brain tumors are the most common solid cancer in children and are
traditionally diagnosed via a tissue biopsy or resection. Liquid biopsy offers the possibility to …
traditionally diagnosed via a tissue biopsy or resection. Liquid biopsy offers the possibility to …
[HTML][HTML] An unusual association of deletion of SMARCB1 in a patient with intracranial yolk sac tumor: A case-report
A Gupte, E Al-Antary, K Regling, WJ Kupsky… - Pediatric Hematology …, 2024 - Elsevier
Background Deletion of SMARCB1/loss of INI is a well-known association in atypical
rhabdoid teratoid tumors (ATRT) in the brain, rhabdoid tumors in the kidney, and less …
rhabdoid teratoid tumors (ATRT) in the brain, rhabdoid tumors in the kidney, and less …
Molecular alterations of low-grade gliomas in young patients: Strategies and platforms for routine evaluation
I Dandapath, R Chakraborty, K Kaur… - Neuro-Oncology …, 2021 - academic.oup.com
In recent years, it has been established that molecular biology of pediatric low-grade
gliomas (PLGGs) is entirely distinct from adults. The majority of the circumscribed pediatric …
gliomas (PLGGs) is entirely distinct from adults. The majority of the circumscribed pediatric …