Mechanistic insights into eosinophilic esophagitis: therapies targeting pathophysiological mechanisms

S Massironi, G Mulinacci, C Gallo, A Elvevi, S Danese… - Cells, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by
eosinophilic infiltration of the esophagus. It arises from a complex interplay of genetic …

Comparison of drugs for active eosinophilic oesophagitis: systematic review and network meta-analysis

P Visaggi, B Barberio, G Del Corso, N de Bortoli… - Gut, 2023 - gut.bmj.com
Background There is currently no recommendation regarding preferred drugs for active
eosinophilic oesophagitis (EoE) because their relative efficacy is unclear. We conducted an …

Eosinophil depletion with benralizumab for eosinophilic esophagitis

ME Rothenberg, ES Dellon, MH Collins… - … England Journal of …, 2024 - Mass Medical Soc
Background Benralizumab is an eosinophil-depleting anti–interleukin-5 receptor α
monoclonal antibody. The efficacy and safety of benralizumab in patients with eosinophilic …

Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition …

J Amil‐Dias, S Oliva, A Papadopoulou… - Journal of Pediatric …, 2024 - Wiley Online Library
Abstract Introduction Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the
esophagus characterized by symptoms of esophageal dysfunction and histologically by …

Non-invasive and minimally invasive biomarkers for the management of eosinophilic esophagitis beyond peak eosinophil counts: filling the gap in clinical practice

P Visaggi, I Solinas, F Baiano Svizzero, A Bottari… - Diagnostics, 2023 - mdpi.com
Eosinophilic esophagitis (EoE) is a chronic esophageal disease that needs lifelong
management and follow-up. The diagnosis requires an upper endoscopy with at least one …

Current and novel therapies for eosinophilic gastrointestinal diseases

G Marasco, P Visaggi, M Vassallo, M Fiocca… - International Journal of …, 2023 - mdpi.com
Eosinophilic gastrointestinal diseases (EGIDs) are an emerging group of pathological
entities characterized by an eosinophil-predominant infiltration of different tracts of the gut in …

Unveiling the human gastrointestinal tract microbiome: the past, present, and future of metagenomics

K Athanasopoulou, PG Adamopoulos, A Scorilas - Biomedicines, 2023 - mdpi.com
Over 1014 symbiotic microorganisms are present in a healthy human body and are
responsible for the synthesis of vital vitamins and amino acids, mediating cellular pathways …

Artificial intelligence tools for the diagnosis of eosinophilic esophagitis in adults reporting dysphagia: development, external validation, and software creation for point …

P Visaggi, G Del Corso, FB Svizzero, M Ghisa… - The Journal of Allergy …, 2024 - Elsevier
Background Despite increased awareness of eosinophilic esophagitis (EoE), the diagnostic
delay has remained stable over the past 3 decades. There is a need to improve the …

Eosinophilic esophagitis: does age matter?

S Massironi, A Elvevi, R Panceri… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of
the esophagus with increasing prevalence worldwide. It is a multifactorial disease caused by …

Emerging role of alarmins in food allergy: an update on pathophysiological insights, potential use as disease biomarkers, and therapeutic implications

A Rizzi, E Lo Presti, R Chini, L Gammeri… - Journal of Clinical …, 2023 - mdpi.com
Food allergies are immuno-mediated adverse reactions to ingestion or contact with foods,
representing a widespread health problem. The immune response can be IgE-mediated …