Exosomal circRNA: emerging insights into cancer progression and clinical application potential

F Zhang, J Jiang, H Qian, Y Yan, W Xu - Journal of Hematology & …, 2023 - Springer
Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …

Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression

J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …

Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression

G Liang, Y Ling, M Mehrpour, PE Saw, Z Liu, W Tan… - Molecular cancer, 2020 - Springer
Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …

KRT17 promotes T-lymphocyte infiltration through the YTHDF2–CXCL10 axis in colorectal cancer

W Liang, H Liu, Z Zeng, Z Liang, H Xie, W Li… - Cancer immunology …, 2023 - AACR
Poor infiltration of T lymphocytes has been regarded as a crucial mechanism of tumor
immune escape. Here, we demonstrate a protective role of KRT17 in colorectal cancer …

[HTML][HTML] Circular RNAs in cancer: limitations in functional studies and diagnostic potential

F Li, Q Yang, AT He, BB Yang - Seminars in cancer biology, 2021 - Elsevier
Circular RNAs (circRNAs) are a large class of noncoding RNAs, generated from a process
called back-splicing, that possess critical regulatory functions in many cellular events. A …

Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop

Y Wang, Q Yan, Y Mo, Y Liu, Y Wang, S Zhang, C Guo… - Molecular cancer, 2022 - Springer
Abstract Background Circular RNAs play an important role in tumor genesis and
progression, but they have not been sufficiently studied in patients with nasopharyngeal …

A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer

L Xiong, H Liu, C Zhou, X Yang, L Huang, H Jie… - Molecular Cancer, 2023 - Springer
Background Hypoxia is a hallmark of solid tumors and leads to the metabolic
reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and …

MNX1-AS1 promotes phase separation of IGF2BP1 to drive c-Myc–mediated cell-cycle progression and proliferation in lung cancer

Q Zhu, C Zhang, T Qu, X Lu, X He, W Li, D Yin, L Han… - Cancer Research, 2022 - AACR
Abstract c-Myc and E2F1 play critical roles in many human cancers. As long noncoding
RNAs (lncRNA) are known to regulate various tumorigenic processes, elucidation of …

circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling

J Zhu, Y Luo, Y Zhao, Y Kong, H Zheng, Y Li, B Gao… - Molecular Therapy, 2021 - cell.com
Lymphatic metastasis constitutes a leading cause of recurrence and mortality in bladder
cancer. Accumulating evidence indicates that lymphangiogenesis is indispensable to trigger …

Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36

H Ji, TW Kim, WJ Lee, SD Jeong, YB Cho, HH Kim - Molecular Cancer, 2022 - Springer
Abstract Background Circular RNAs (circRNAs) play a critical role in colorectal cancer
(CRC) progression, including metastasis. However, the detailed molecular mechanism is not …