Exosomal circRNA: emerging insights into cancer progression and clinical application potential
F Zhang, J Jiang, H Qian, Y Yan, W Xu - Journal of Hematology & …, 2023 - Springer
Exosomal circRNA serves a novel genetic information molecule, facilitating communication
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …
between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and …
Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression
J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …
Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression
Abstract Background Although both circular RNAs (circRNAs) and autophagy are associated
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …
with the function of breast cancer (BC), whether circRNAs regulate BC progression via …
KRT17 promotes T-lymphocyte infiltration through the YTHDF2–CXCL10 axis in colorectal cancer
Poor infiltration of T lymphocytes has been regarded as a crucial mechanism of tumor
immune escape. Here, we demonstrate a protective role of KRT17 in colorectal cancer …
immune escape. Here, we demonstrate a protective role of KRT17 in colorectal cancer …
[HTML][HTML] Circular RNAs in cancer: limitations in functional studies and diagnostic potential
Circular RNAs (circRNAs) are a large class of noncoding RNAs, generated from a process
called back-splicing, that possess critical regulatory functions in many cellular events. A …
called back-splicing, that possess critical regulatory functions in many cellular events. A …
Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Y Wang, Q Yan, Y Mo, Y Liu, Y Wang, S Zhang, C Guo… - Molecular cancer, 2022 - Springer
Abstract Background Circular RNAs play an important role in tumor genesis and
progression, but they have not been sufficiently studied in patients with nasopharyngeal …
progression, but they have not been sufficiently studied in patients with nasopharyngeal …
A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
L Xiong, H Liu, C Zhou, X Yang, L Huang, H Jie… - Molecular Cancer, 2023 - Springer
Background Hypoxia is a hallmark of solid tumors and leads to the metabolic
reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and …
reprogramming of cancer cells. The role of epigenetic regulation between hypoxia and …
MNX1-AS1 promotes phase separation of IGF2BP1 to drive c-Myc–mediated cell-cycle progression and proliferation in lung cancer
Q Zhu, C Zhang, T Qu, X Lu, X He, W Li, D Yin, L Han… - Cancer Research, 2022 - AACR
Abstract c-Myc and E2F1 play critical roles in many human cancers. As long noncoding
RNAs (lncRNA) are known to regulate various tumorigenic processes, elucidation of …
RNAs (lncRNA) are known to regulate various tumorigenic processes, elucidation of …
circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling
J Zhu, Y Luo, Y Zhao, Y Kong, H Zheng, Y Li, B Gao… - Molecular Therapy, 2021 - cell.com
Lymphatic metastasis constitutes a leading cause of recurrence and mortality in bladder
cancer. Accumulating evidence indicates that lymphangiogenesis is indispensable to trigger …
cancer. Accumulating evidence indicates that lymphangiogenesis is indispensable to trigger …
Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36
H Ji, TW Kim, WJ Lee, SD Jeong, YB Cho, HH Kim - Molecular Cancer, 2022 - Springer
Abstract Background Circular RNAs (circRNAs) play a critical role in colorectal cancer
(CRC) progression, including metastasis. However, the detailed molecular mechanism is not …
(CRC) progression, including metastasis. However, the detailed molecular mechanism is not …