Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling

Y Li, Q Jiang - Frontiers in Immunology, 2023 - frontiersin.org
Inflammasomes are supramolecular platforms that organize in response to various damage-
associated molecular patterns and pathogen-associated molecular patterns. Upon …

Translational Relevance of Advanced Age and Atherosclerosis in Preclinical Trials of Biotherapies for Peripheral Artery Disease

KA Webster - Genes, 2024 - mdpi.com
Approximately 6% of adults worldwide suffer from peripheral artery disease (PAD), primarily
caused by atherosclerosis of lower limb arteries. Despite optimal medical care and …

The Inflammatory Gene PYCARD of the Entorhinal Cortex as an Early Diagnostic Target for Alzheimer's Disease

W Liu, S Chen, X Rao, Y Yang, X Chen, L Yu - Biomedicines, 2023 - mdpi.com
The incidence of Alzheimer's disease (AD) is increasing year by year, which brings great
challenges to human health. However, the pathogenesis of AD is still unclear, and it lacks …

Astrocyte-mediated immune modulation during mycobacterial infection

S Geyer - 2023 - open.uct.ac.za
Central nervous system tuberculosis (CNS-TB) is the severest clinical extra-pulmonary
manifestation of tuberculosis (TB) disease and constitutes approximately 1% of global …

Ativação do inflamassoma ea produção de IL-1 em macrófagos de camundongos selecionados para diferente capacidade inflamatória

LF Monteleone - 2023 - teses.usp.br
Camundongos geneticamente selecionados para máxima (AIRmax) e mínima (AIRmin)
resposta inflamatória aguda têm sido empregados em diversos estudos sobre fatores …