Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

Millions of people visit high-altitude regions annually and more than 80 million live
permanently above 2,500 m. Acute high-altitude exposure can trigger high-altitude illnesses …

It is now widely recognised that the environment in space activates a diverse set of genes
involved in regulating fundamental cellular pathways. This includes the activation of genes …

Excessive erythrocytosis (EE) is a major hallmark of patients suffering from chronic mountain
sickness (CMS, also known as Monge's disease) and is responsible for major morbidity and …

Alzheimer's disease (AD) is a prevalent type of dementia in elderly populations with a
significant genetic component. The accumulating evidence suggests that AD involves a …

Met can function through the mTOR signaling pathway, but the molecular mechanism is not
fully understood. Here we investigated the role of ARID1B in this regulatory process …

Composite lymphoma (CL) is rare, and its incidence is approximately 1.0%–4.7% of all
lymphomas. CL is defined as the concurrent or sequential occurrence of two or more distinct …

Background The differentiation of hematopoietic stem cells towards their different cell fates,
has been difficult to study experimentally due to the diverse number of physiological …

Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …

This three-parts thesis presents discovery of the molecular mechanisms underpinning
hematopoiesis and its dysregulation in cancer. Identifying tumor suppressor genes on …