Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …

Uric acid is the final product of purine metabolism and is converted to allantoin in most
mammals via the uricase enzyme. The accumulation of loss of function mutations in the …

The microbes and microbial pathways that influence host inflammatory disease progression
remain largely undefined. Here, we show that variation in atherosclerosis burden is partially …

The brain and gut are intricately connected and respond to various stimuli. Stress-induced
brain-gut communication is implicated in the pathogenesis and relapse of gut disorders. The …

Hyperuricemia induces inflammatory arthritis and accelerates the progression of renal and
cardiovascular diseases. Gut microbiota has been linked to the development of …

Elevated bloodstream levels of uric acid, a mammalian purine degradation product, are
associated with several noncommunicable diseases. Recent studies by Kasahara et al. and …

Owing to renal reabsorption and the loss of uricase activity, uric acid (UA) is strictly
maintained at a higher physiological level in humans than in other mammals, which …

The effect of strong metal–support interaction (SMSI) has never been systematically studied
in the field of nanozyme-based catalysis before. Herein, by coupling two different Pd crystal …

In the past two decades, the rapid increase in the incidence of metabolic diseases, including
obesity, diabetes, dyslipidemia, non-alcoholic fatty liver disease, hypertension, and …

Hyperuricemia (HUA) has emerged as a public health burden. Recently, lactic acid bacteria
(LAB) were reported to possess potential for alleviating HUA. However, LABs with anti-HUA …