An imbalance between excitation and inhibition has been a longstanding proposed
mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to …

The prevailing understanding of generalized epilepsy is shaped by the traditional definition
that “the responsible neuronal discharge takes place, if not throughout the entire grey matter …

Conventionally, epilepsy is dichotomized into distinct “focal” and “generalized” categories.
However, many studies have reported so‐called focal features among patients with …

In the majority of neuropsychiatric conditions, marked gender-based differences have been
found in the epidemiology, clinical manifestations, and therapy of disease. Emerging data …

PURPOSE: To investigate if phenotypic variations have prognostic implications in juvenile
myoclonic epilepsy (JME). METHODS: Sixty-five consecutive JME patients had video-EEG …

Advanced neuroimaging techniques have been utilised with ever increasing frequency over
the last 10 years. A range of structural and functional imaging modalities have been …

Alterations in both structural connectivity (SC) and functional connectivity (FC) have been
reported in temporal lobe epilepsy (TLE). However, the relationship between FC and SC …

Objective Juvenile myoclonic epilepsy (JME) has been considered to be a frontal variant of
thalamocortical network dysfunction in epilepsy. Changes of γ‐aminobutyric acid (GABA) …

Objectives Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy marked by
cortical hyperexcitability. Recent neuroimaging data suggested also a thalamic role in …

Cognitive impairment and personality disorders are severe comorbidities commonly
observed in patients with epilepsy, and together they decrease the quality of patients' life …