Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …

The year 2014 marked the 20th anniversary of the coining of the term proteomics. The
purpose of this scientific statement is to summarize advances over this period that have …

Sex differences in heart failure development following myocardial infarction (MI) are not fully
understood. We hypothesized that differential MI signaling could explain variations in …

Despite current optimal therapeutic regimens, approximately one in four patients diagnosed
with myocardial infarction (MI) will go on to develop congestive heart failure, and heart …

Pathological changes resulting from myocardial infarction (MI) include extracellular matrix
alterations of the left ventricle, which can lead to cardiac stiffness and impair systolic and …

The ischemic injury caused by myocardial infarction activates a complex healing process
wherein a powerful inflammatory response and a reparative phase follow and balance each …

Abstract Matrix metalloproteinase-9 (MMP-9) is robustly elevated in the first week post-
myocardial infarction (MI). Targeted deletion of the MMP-9 gene attenuates cardiac …

Extracellular matrix (ECM) has emerged as a dynamic tissue component, providing not only
structural support, but also functionally participating in a wide range of signaling events …

Oxidative stress, caused by the over production of oxidants or inactivity of antioxidants, can
modulate the redox state of several target proteins such as tyrosine kinases, mitogen …

Introduction: The cardiac extracellular matrix (ECM) provides anatomical, biochemical, and
physiological support to the left ventricle. ECM proteins are difficult to detect using unbiased …