Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …
rich sequences, and has profound implications for various pharmacological and biological …
G-quadruplexes and helicases
O Mendoza, A Bourdoncle, JB Boulé… - Nucleic acids …, 2016 - academic.oup.com
Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-
quadruplexes. These structures may be very stable under physiological conditions …
quadruplexes. These structures may be very stable under physiological conditions …
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
G Liu, W Du, X Sang, Q Tong, Y Wang, G Chen… - Nature …, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have
devastating consequences worldwide. Recently, great efforts have been made to identify …
devastating consequences worldwide. Recently, great efforts have been made to identify …
RNA G-quadruplexes: emerging mechanisms in disease
A Cammas, S Millevoi - Nucleic acids research, 2017 - academic.oup.com
Abstract RNA G-quadruplexes (G4s) are formed by G-rich RNA sequences in protein-coding
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
(mRNA) and non-coding (ncRNA) transcripts that fold into a four-stranded conformation …
Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications
YV Suseela, N Narayanaswamy, S Pratihar… - Chemical Society …, 2018 - pubs.rsc.org
The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Non-canonical DNA structures: Diversity and disease association
A complete understanding of DNA double-helical structure discovered by James Watson
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
and Francis Crick in 1953, unveil the importance and significance of DNA. For the last seven …
G-quadruplex-binding proteins: promising targets for drug design
H Shu, R Zhang, K Xiao, J Yang, X Sun - Biomolecules, 2022 - mdpi.com
G-quadruplexes (G4s) are non-canonical secondary nucleic acid structures. Sequences with
the potential to form G4s are abundant in regulatory regions of the genome including …
the potential to form G4s are abundant in regulatory regions of the genome including …
G-quadruplex unwinding helicases and their function in vivo
M Sauer, K Paeschke - Biochemical Society Transactions, 2017 - portlandpress.com
The concept that G-quadruplex (G4) structures can form within DNA or RNA in vitro has
been long known and extensively discussed. In recent years, accumulating evidences imply …
been long known and extensively discussed. In recent years, accumulating evidences imply …
TERRA G-quadruplex RNA interaction with TRF2 GAR domain is required for telomere integrity
Telomere dysfunction causes chromosomal instability which is associated with many
cancers and age-related diseases. The non-coding telomeric repeat-containing RNA …
cancers and age-related diseases. The non-coding telomeric repeat-containing RNA …