The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Nuclear pore complexes (NPCs) fuse the inner and outer nuclear membranes to form
channels across the nuclear envelope. They are large macromolecular assemblies with a …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …

Proximity-dependent biotin identification (BioID) is a method for identifying protein
associations that occur in vivo. By fusing a promiscuous biotin ligase to a protein of interest …

The nuclear pore complex (NPC) is a fundamental component of all eukaryotic cells that
facilitates nucleocytoplasmic exchange of macromolecules. It is assembled from multiple …

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

During the co-translational assembly of protein complexes, a fully synthesized subunit
engages with the nascent chain of a newly synthesized interaction partner. Such events are …

The hallmark of eukaryotic cells is the nucleus that contains the genome, enclosed by a
physical barrier known as the nuclear envelope (NE). On the one hand, this …

The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional
nucleocytoplasmic transport. We present the reconstitution and interdisciplinary analyses of …

Abstract Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore
complexes exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that …