The therapeutic potential of targeting regulated non-apoptotic cell death

K Hadian, BR Stockwell - Nature Reviews Drug Discovery, 2023 - nature.com
Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

The multifaceted role of ferroptosis in liver disease

J Chen, X Li, C Ge, J Min, F Wang - Cell Death & Differentiation, 2022 - nature.com
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …

The development of the concept of ferroptosis

T Hirschhorn, BR Stockwell - Free Radical Biology and Medicine, 2019 - Elsevier
The term ferroptosis was coined in 2012 to describe an iron-dependent regulated form of
cell death caused by the accumulation of lipid-based reactive oxygen species; this type of …

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Y Li, D Feng, Z Wang, Y Zhao, R Sun, D Tian… - Cell Death & …, 2019 - nature.com
Ferroptosis is a recently identified form of regulated cell death defined by the iron-dependent
accumulation of lipid reactive oxygen species. Ferroptosis has been studied in various …

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

L Galluzzi, I Vitale, SA Aaronson, JM Abrams… - Cell Death & …, 2018 - nature.com
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors

C Scarpellini, G Klejborowska, C Lanthier… - Trends in …, 2023 - cell.com
Ferroptosis is an iron-catalysed form of regulated cell death, which is critically dependent on
phospholipid peroxidation of cellular membranes. Ferrostatin 1 was one of the first synthetic …

Targeting ferroptosis protects against experimental (multi) organ dysfunction and death

S Van Coillie, E Van San, I Goetschalckx… - Nature …, 2022 - nature.com
The most common cause of death in the intensive care unit (ICU) is the development of
multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure …

The chemistry and biology of ferroptosis

BR Stockwell, X Jiang - Cell chemical biology, 2020 - cell.com
Ferroptosis is a recently described form of cell death driven by iron-dependent lipid
peroxidation. This type of cell death was first observed in response to treatment of tumor …

On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death

O Zilka, R Shah, B Li, JP Friedmann Angeli… - ACS central …, 2017 - ACS Publications
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation
of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative …