Alterations in glutamatergic neurotransmission are implicated in the pathophysiology of
depression, and the glutamatergic system represents a treatment target for depression. To …

Major depressive disorder (MDD) is a leading cause of distress, disability, and suicides. As
per the latest WHO report, MDD affects more than 260 million people worldwide. Despite …

Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …

Background: Stress is a common reaction to an environmental adversity, but a dysregulation
of the stress response can lead to psychiatric illnesses such as major depressive disorder …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …

Background There is evidence that substance use disorders and other mental disorders may
have shared biological mechanisms. However, the neurobiological basis of this comorbidity …

Neuropsychiatric disorders including generalized anxiety disorder (GAD), obsessive-
compulsive disorder (OCD), major depressive disorder (MDD), bipolar disorder (BD), and …

Herein, we have reviewed the role of glutamate, the major excitatory neurotransmitter in the
brain, in a number of neurochemical,-physiological, and-behavioral processes mediating the …

Background Life expectancy is greatly reduced in individuals presenting alcohol use
disorders and chronic smoking. Literature studies suggest that common mechanisms may …

Rationale and objectives The amino acid l-theanine (N-ethyl-l-glutamine) has historically
been considered a relaxing agent. In the present study, we examined the effects of repeated …