Enabling replicative immortality and uncontrolled cell cycle are hallmarks of cancer cells.
Minichromosome maintenance proteins (MCMs) exhibit helicase activity in replication …

DNA replicates once per cell cycle. Interfering with the regulation of DNA replication
initiation generates genome instability through over-replication and has been linked to early …

Abstract The minichromosome maintenance (MCM) 8/9 helicase is a AAA+ complex
involved in DNA replication-associated repair. Despite high sequence homology to the …

Protein is very important for almost all living creatures because it participates in most
complicated and essential biological processes. Determining the functions of given proteins …

Genotoxic stress leads to DNA damage which can be detrimental to the cell. A well‐
orchestrated cellular response is mounted to manage and repair the genotoxic stress …

Green nanotechnology is considered a promising method to construct functional materials
with significant anticancer activity, while overcoming the shortcomings of traditional …

Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma
(LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) …

The six-subunit origin recognition complex (ORC), a DNA replication initiator, defines the
localization of the origins of replication in eukaryotes. The Orc6 subunit is the smallest and …

The minichromosome maintenance (MCM) complex acts as a DNA helicase during DNA
replication, and thereby regulates cell cycle progression and proliferation. In addition, MCM …

Colorectal cancer (CRC) is one of the most common tumors worldwide and is associated
with high mortality. Here we performed bioinformatics analysis, which we validated using …