Androgen receptor in prostate cancer
CA Heinlein, C Chang - Endocrine reviews, 2004 - academic.oup.com
The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …
through the androgen receptor (AR). AR remains important in the development and …
Development of selective androgen receptor modulators (SARMs)
Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …
Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy
X-LINKED spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of
motorneuron disease which may be associated with signs of androgen insensitivity. We …
motorneuron disease which may be associated with signs of androgen insensitivity. We …
The androgen receptor gene mutations database: 2012 update
B Gottlieb, LK Beitel, A Nadarajah, M Paliouras… - Human …, 2012 - Wiley Online Library
The current version of the androgen receptor gene (AR) mutations database is described. A
major change to the database is that the nomenclature and numbering scheme now …
major change to the database is that the nomenclature and numbering scheme now …
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion–resistant growth
Z Guo, X Yang, F Sun, R Jiang, DE Linn, H Chen… - Cancer research, 2009 - AACR
The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …
Molecular genetic basis of the histo-blood group ABO system
F Yamamoto, H Clausen, T White, J Marken… - Nature, 1990 - nature.com
The histo-blood group ABO, the major human alloantigen system, involves three
carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities …
carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities …
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer
ME Taplin, GJ Bubley, TD Shuster… - … England Journal of …, 1995 - Mass Medical Soc
Background Metastatic prostate cancer is a leading cause of cancer-related death in men.
The rate of response to androgen ablation is high, but most patients relapse as a result of …
The rate of response to androgen ablation is high, but most patients relapse as a result of …
Androgens and bone
D Vanderschueren, L Vandenput, S Boonen… - Endocrine …, 2004 - academic.oup.com
Loss of estrogens or androgens increases the rate of bone remodeling by removing
restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal …
restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal …
The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
MR Koelle, WS Talbot, WA Segraves, MT Bender… - Cell, 1991 - cell.com
The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue
development that result in metamorphosis. To advance our understanding of the genetic …
development that result in metamorphosis. To advance our understanding of the genetic …
Advancing genomic technologies and clinical awareness accelerates discovery of disease-associated tandem repeat sequences
T Gall-Duncan, N Sato, RKC Yuen… - Genome …, 2022 - genome.cshlp.org
Expansions of gene-specific DNA tandem repeats (TRs), first described in 1991 as a
disease-causing mutation in humans, are now known to cause> 60 phenotypes, not just …
disease-causing mutation in humans, are now known to cause> 60 phenotypes, not just …