The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

X-LINKED spinal and bulbar muscular atrophy (Kennedy's disease) is an adult-onset form of
motorneuron disease which may be associated with signs of androgen insensitivity. We …

The current version of the androgen receptor gene (AR) mutations database is described. A
major change to the database is that the nomenclature and numbering scheme now …

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …

The histo-blood group ABO, the major human alloantigen system, involves three
carbohydrate antigens (ABH). A, B and AB individuals express glycosyltransferase activities …

Background Metastatic prostate cancer is a leading cause of cancer-related death in men.
The rate of response to androgen ablation is high, but most patients relapse as a result of …

Loss of estrogens or androgens increases the rate of bone remodeling by removing
restraining effects on osteoblastogenesis and osteoclastogenesis, and also causes a focal …

The steroid hormone ecdysone triggers coordinate changes in Drosophila tissue
development that result in metamorphosis. To advance our understanding of the genetic …

Expansions of gene-specific DNA tandem repeats (TRs), first described in 1991 as a
disease-causing mutation in humans, are now known to cause> 60 phenotypes, not just …