The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance
and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae …

There are several bacteria called superbugs that are resistant to multiple antibiotics which
can be life threatening specially for critically ill and hospitalized patients. This article …

Background: The superiority of combination therapy for carbapenem-resistant Gram-
negative bacilli (CR-GNB) remains controversial. In vitro models may predict the efficacy of …

Background It is often challenging to select appropriate combination therapies to treat
infections caused by carbapenem-resistant Enterobacterales (CRE) with high-level …

The purpose of this study was to investigate the synergistic and bactericidal effects of
combinations of colistin with meropenem or amikacin in vitro and provide laboratory data …

Significance: The crisis of antimicrobial resistance (AMR) increases dramatically despite all
efforts to use available antibiotics or last resort antimicrobial agents. The spread of the AMR …

Fosfomycin has emerged as a very useful antimicrobial in management of extremely drug
resistant (XDR) and pan drug resistant (PDR) Klebsiella pneumoniae. In this study, we …

With the irrational use of antibiotics and the increasing abuse of oral antibiotics, the drug
resistance of gastrointestinal pathogens has become a prominent problem in clinical …

Bloodstream infection (BSI) is defined by the presence of microbes in the bloodstream and
has high mortality. Early antimicrobial therapy is key to treating BSI patients. Because of …

Background: To investigate the activity of 5 antibiotic monotherapies, including colistin
(COL), meropenem (MEM), amikacin (AMK), levofloxacin (LEV), and tigecycline (TGC) …