Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Many metals are essential for living organisms, but at higher doses they may be toxic and
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …

The increasing utilization of heavy metals in modern industries leads to an increase in the
environmental burden. Nickel represents a good example of a metal whose use is widening …

For several exposures, it has been proved that chemicals can alter epigenetic marks, and
that the same or similar epigenetic alterations can be found in patients with the disease of …

Abstract The European Commission asked EFSA to update its previous Opinion on nickel in
food and drinking water, taking into account new occurrence data, the updated benchmark …

Chronic exposure to nickel (II), chromium (VI), or inorganic arsenic (iAs) has long been
known to increase cancer incidence among affected individuals. Recent epidemiological …

Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Human exposure to highly nickel-polluted environments, such as those associated with
nickel refining, electroplating, and welding, has the potential to produce a variety of …

The interplay of the presence of nickel and protein disorder in processes affecting human
health is the focus of the present review. Many systems involving nickel as either a cofactor …

Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …