Base editing: precision chemistry on the genome and transcriptome of living cells
RNA-guided programmable nucleases from CRISPR systems generate precise breaks in
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …
DNA or RNA at specified positions. In cells, this activity can lead to changes in DNA …
Clonal expansion in non-cancer tissues
N Kakiuchi, S Ogawa - Nature Reviews Cancer, 2021 - nature.com
Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …
The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance
In this study, the impact of the apolipoprotein B mRNA-editing catalytic subunit-like
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
(APOBEC) enzyme APOBEC3B (A3B) on epidermal growth factor receptor (EGFR)-driven …
Mechanisms of APOBEC3 mutagenesis in human cancer cells
M Petljak, A Dananberg, K Chu, EN Bergstrom… - Nature, 2022 - nature.com
The APOBEC3 family of cytosine deaminases has been implicated in some of the most
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
prevalent mutational signatures in cancer,–. However, a causal link between endogenous …
Therapy-induced APOBEC3A drives evolution of persistent cancer cells
Acquired drug resistance to anticancer targeted therapies remains an unsolved clinical
problem. Although many drivers of acquired drug resistance have been identified,,–, the …
problem. Although many drivers of acquired drug resistance have been identified,,–, the …
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
The single-stranded DNA cytosine-to-uracil deaminase APOBEC3B is an antiviral protein
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
implicated in cancer. However, its substrates in cells are not fully delineated. Here …
Identification of shared and disease-specific host gene–microbiome associations across human diseases using multi-omic integration
While gut microbiome and host gene regulation independently contribute to gastrointestinal
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
disorders, it is unclear how the two may interact to influence host pathophysiology. Here we …
Endogenous DNA damage as a source of genomic instability in cancer
A Tubbs, A Nussenzweig - Cell, 2017 - cell.com
Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
[HTML][HTML] Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer
Tumor mutational burden and heterogeneity has been suggested to fuel resistance to many
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
targeted therapies. The cytosine deaminase APOBEC proteins have been implicated in the …
A-to-I RNA editing—immune protector and transcriptome diversifier
E Eisenberg, EY Levanon - Nature Reviews Genetics, 2018 - nature.com
Modifications of RNA affect its function and stability. RNA editing is unique among these
modifications because it not only alters the cellular fate of RNA molecules but also alters …
modifications because it not only alters the cellular fate of RNA molecules but also alters …