Organelle-targeted activatable photosensitizers are attractive to improve the specificity and
controllability of photodynamic therapy (PDT), however, they suffer from a big problem in the …

Photodynamic therapy (PDT) is an effective and promising cancer treatment. PDT directly
generates reactive oxygen species (ROS) through photochemical reactions. This oxygen …

Background Photoactivity, though known for centuries, is only recently shifting back into
focus as a treatment option against cancer and microbial infections. The external factor light …

The dense cancer microenvironment is a significant barrier that limits the penetration of
anticancer agents, thereby restraining the efficacy of molecular and nanoscale cancer …

Highly efficient triplet photosensitizers (PSs) have attracted increasing attention in cancer
photodynamic therapy where photo-induced reactive oxygen species (ROSs, such as singlet …

The clinical use of cisplatin are limited due to its drug resistance. Thus, it is urgent to find
effective combination therapy that sensitizes tumor cells to this drug. The combined chemo …

Objectives Photodynamic therapy (PDT) is a promising approach for cancer treatment, and
the underlying signalling pathway changes has been carried out for studying the PDT …

Phenalenone is a synthetically accessible, highly efficient photosensitizer with a near-unity
singlet oxygen quantum yield. Unfortunately, its UV absorption and lack of fluorescence has …

Abstract Human NAD (P) H: Quinone Oxidoreductase 1 (hNQO1) is an attractive enzyme for
cancer therapeutics due to its significant overexpression in tumors compared to healthy …

A series of functionalized 6-alkoxy phenalenones was prepared through an unprecedented
oxidative dealkylation of readily available phenalene precursors. The starting phenalenes …