The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial
and destructive potentials. It can exert opposing actions triggering either neuron survival …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Background Neuroanatomical alterations have been associated with cognitive deficits in
mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal …

Background Neuroinflammation following traumatic brain injury (TBI) has been shown to be
associated with secondary injury development; however, how systemic inflammatory …

Background Post-surgical pain that lingers beyond the initial few-week period of tissue
healing is a major predictor of pain chronification, which leads to substantial disability and …

Repetitive blast traumatic brain injury (TBI) affects numerous soldiers on the battlefield. Mild
TBI has been shown to have long-lasting effects with repeated injury. We have investigated …

Protecting the nervous system from chronic effects of physical and chemical stress is a
pressing clinical challenge. The obligate pro-degenerative protein Sarm1 is essential for …

T cells participate in the repair process and immune response in the CNS post‐traumatic
injury and play both a beneficial and harmful role. Together with nerve cells and other …

Identifying differential responses between sexes following traumatic brain injury (TBI) can
elucidate the mechanisms behind disease pathology. Peripheral and central inflammation in …

Traumatic brain injury (TBI) represents a major public health problem, which is associated
with neurological dysfunction. In severe or moderate cases of TBI, in addition to its high …