CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Rare diseases affect 30 million people in the USA and more than 300–400 million
worldwide, often causing chronic illness, disability, and premature death. Traditional …

Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …

The primary cilium is a hair-like surface-exposed organelle of the eukaryotic cell that
decodes a variety of signals—such as odorants, light and Hedgehog morphogens—by …

The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Signaling pathways that mediate cell-cell communication are essential for collective cell
behaviors in multicellular systems. The hedgehog (HH) pathway, first discovered and …

The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

A central question in the post-genomic era is how genes interact to form biological
pathways. Measurements of gene dependency across hundreds of cell lines have been …

Cilia are surface-exposed organelles that dynamically concentrate signaling molecules to
organize sensory, developmental and homeostatic pathways. Entry and exit of signaling …

The genomes of living lungfishes can inform on the molecular-developmental basis of the
Devonian sarcopterygian fish–tetrapod transition. We de novo sequenced the genomes of …