The molecular mechanisms and signalling pathways that regulate the in vitro preservation of
distinct pluripotent stem cell configurations, and their induction in somatic cells by direct …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

The transcription factor Sox2 maintains the pluripotency of early embryonic cells and
regulates the formation of several epithelia during fetal development. Whether Sox2 …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Spermatogonial stem cells (SSCs) are the most primitive spermatogonia in the testis and
have an essential role to maintain highly productive spermatogenesis by self-renewal and …

Pluripotent stem cells can be derived from embryos or induced from adult cells by
reprogramming. They are unique among stem cells in that they can give rise to all cell types …

The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on
regulatory programs that govern self-renewal and differentiation and somatic cell …

Specific cells within the early mammalian embryo have the capacity to generate all somatic
lineages plus the germline. This property of pluripotency is confined to the epiblast, a …

Spermatogenesis originates from spermatogonial stem cells (SSCs). Development of the
spermatogonial transplantation technique in 1994 provided the first functional assay to …

Recent years have witnessed the expansion of tissue failures and diseases. The uprising of
regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue …