The micromechanics of lung alveoli: structure and function of surfactant and tissue components

L Knudsen, M Ochs - Histochemistry and cell biology, 2018 - Springer
The mammalian lung´ s structural design is optimized to serve its main function: gas
exchange. It takes place in the alveolar region (parenchyma) where air and blood are …

Cross-talk between alveolar macrophages and lung epithelial cells is essential to maintain lung homeostasis

EY Bissonnette, JF Lauzon-Joset, JS Debley… - Frontiers in …, 2020 - frontiersin.org
The main function of the lung is to perform gas exchange while maintaining lung
homeostasis despite environmental pathogenic and non-pathogenic elements contained in …

Physiological roles of macrophages

S Gordon, L Martinez-Pomares - Pflügers Archiv-European Journal of …, 2017 - Springer
Macrophages are present in mammals from midgestation, contributing to physiologic
homeostasis throughout life. Macrophages arise from yolk sac and foetal liver progenitors …

Origin and ontogeny of lung macrophages: from mice to humans

E Evren, E Ringqvist, T Willinger - Immunology, 2020 - Wiley Online Library
Macrophages are tissue‐resident myeloid cells with essential roles in host defense, tissue
repair, and organ homeostasis. The lung harbors a large number of macrophages that …

The Lord of the Lungs: The essential role of pulmonary surfactant upon inhalation of nanoparticles

C Garcia-Mouton, A Hidalgo, A Cruz… - European Journal of …, 2019 - Elsevier
The rapid development of nanotechnology is opening a huge world of promising
possibilities in healthcare, but this is also increasing the necessity to study the potential risk …

Understanding the principle biophysics concepts of pulmonary surfactant in health and disease

C Autilio, J Pérez-Gil - Archives of Disease in Childhood-Fetal and …, 2019 - fn.bmj.com
Pulmonary surfactant (PS) is a lipid-protein complex essential to stabilise the delicate
structure of mammalian alveoli along with successive compression-expansion respiratory …

[HTML][HTML] Restoring pulmonary surfactant membranes and films at the respiratory surface

M Echaide, C Autilio, R Arroyo, J Perez-Gil - Biochimica et Biophysica Acta …, 2017 - Elsevier
Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the
alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There …

Revisiting the role of pulmonary surfactant in chronic inflammatory lung diseases and environmental exposure

N Milad, MC Morissette - European Respiratory Review, 2021 - Eur Respiratory Soc
Pulmonary surfactant is a crucial and dynamic lung structure whose primary functions are to
reduce alveolar surface tension and facilitate breathing. Though disruptions in surfactant …

[HTML][HTML] Pulmonary surfactant and nanocarriers: Toxicity versus combined nanomedical applications

A Hidalgo, A Cruz, J Pérez-Gil - Biochimica et Biophysica Acta (BBA) …, 2017 - Elsevier
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of
breathing, which coats and stabilizes the whole respiratory surface and possesses …

Pulmonary surfactant and drug delivery: Vehiculization, release and targeting of surfactant/tacrolimus formulations

A Hidalgo, C Garcia-Mouton, C Autilio… - Journal of Controlled …, 2021 - Elsevier
This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery
over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS-and …