The role and function of the members of the TGFβ superfamily has been a substantial area
of research focus for the last several decades. During that time, it has become apparent that …

This review aims to highlight the role of silicon in drug discovery. Silicon and carbon are
often regarded as being similar with silicon located directly beneath carbon in the same …

RNA methyltransferases (RNMTs) catalyze the methylation of RNA using S‐adenosyl‐l‐
methionine (SAM) as the methyl donor. Methylation at the N‐6 position of adenosine is the …

Seventeen silyl-and trityl-modified (5′-O-and 3′, 5′-di-O-) nucleosides were synthesized
with the aim of investigating the in vitro antiproliferative activities of these nucleoside …

Abstract Treatment of Boc-protected N 9-aryladenines with 1° alkylamines (1.1 equiv) and
DMAP (1.1 equiv) in DMF at 80° C in the presence of activated 5 Å molecular sieves gave …

The reaction between 1-aminosugars and trimethylisocyanate (TMSNCO) was optimised as
a one-step synthetic strategy for the synthesis of sugar biurets. This protocol was …

Les méthyltransférases d'ARN (RNMTs) catalysent la méthylation d'ARN avec la S-adénosyl-
L-méthionine (SAM) comme donneur du groupement méthyle. La méthylation en position N …

Methods for preparing an array of potential small molecule inhibitors of Bone Morphogenetic
Protein Receptor 1b (BMPR1b) are described. Target molecules were prepared from two …