[HTML][HTML] Collagen code in tumor microenvironment: functions, molecular mechanisms, and therapeutic implications
Q Zhang, ZY An, W Jiang, WL Jin, XY He - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The tumor microenvironment (TME) is crucial in cancer progression, and the extracellular
matrix (ECM) is an important TME component. Collagen is a major ECM component that …
matrix (ECM) is an important TME component. Collagen is a major ECM component that …
Structure of the large ribosomal subunit from human mitochondria
Human mitochondrial ribosomes are highly divergent from all other known ribosomes and
are specialized to exclusively translate membrane proteins. They are linked with hereditary …
are specialized to exclusively translate membrane proteins. They are linked with hereditary …
Personalized immunotherapy against several neuronal and brain tumors
S Kuttruff-coqui, T Weinschenk, J Fritsche… - US Patent …, 2021 - Google Patents
2014-11-12 Assigned to IMMATICS BIOTECHNOLOGIES GMBH reassignment IMMATICS
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
BIOTECHNOLOGIES GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …
DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway
Recurrent breast cancer presents significant challenges with aggressive phenotypes and
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …
treatment resistance. Therefore, novel therapeutics are urgently needed. Here, we report …
[HTML][HTML] Endolysosomal cation channels point the way towards precision medicine of cancer and infectious diseases
CC Chen, E Krogsaeter, CY Kuo, MC Huang… - Biomedicine & …, 2022 - Elsevier
Infectious diseases and cancer are among the key medical challenges that humankind is
facing today. A growing amount of evidence suggests that ion channels in the …
facing today. A growing amount of evidence suggests that ion channels in the …
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation
Colony formation in soft agar is the gold-standard assay for cellular transformation in vitro,
but it is unsuited for high-throughput screening. Here, we describe an assay for cellular …
but it is unsuited for high-throughput screening. Here, we describe an assay for cellular …
[HTML][HTML] Cuproptosis engages in c-Myc-mediated breast cancer stemness
R Wang, K Xu, Q Chen, Q Hu, J Zhang… - Journal of Translational …, 2023 - Springer
Background Intra-tumoral heterogeneity (ITH) is a distinguished hallmark of cancer, and
cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great …
cancer stem cells (CSCs) contribute to this malignant characteristic. Therefore, it is of great …
[HTML][HTML] The cardiac TBX5 interactome reveals a chromatin remodeling network essential for cardiac septation
Human mutations in the cardiac transcription factor gene TBX5 cause congenital heart
disease (CHD), although the underlying mechanism is unknown. We report characterization …
disease (CHD), although the underlying mechanism is unknown. We report characterization …
[HTML][HTML] Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression
MB Morelli, M Nabissi, C Amantini, D Tomassoni… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Abstract The Transient Receptor Potential (TRP) superfamily consists of cation-selective and
non-selective ion channels playing an important role both in sensory physiology and in …
non-selective ion channels playing an important role both in sensory physiology and in …
[HTML][HTML] Type XX collagen is elevated in circulation of patients with solid tumors
J Thorlacius-Ussing, C Jensen, EA Madsen… - International Journal of …, 2022 - mdpi.com
In the tumor microenvironment, the extracellular matrix (ECM) has been recognized as an
important part of cancer development. The dominant ECM proteins are the 28 types of …
important part of cancer development. The dominant ECM proteins are the 28 types of …