With the advent of X-ray free-electron lasers (XFELs), new, high-throughput serial
crystallography techniques for macromolecular structure determination have emerged …

Methanotrophic bacteria represent a potential route to methane utilization and mitigation of
methane emissions. In the first step of their metabolic pathway, aerobic methanotrophs use …

The metal centres in metalloenzymes and molecular catalysts are responsible for the
rearrangement of atoms and electrons during complex chemical reactions, and they enable …

Methane is a potent greenhouse gas that contributes significantly to climate change and is
primarily regulated in Nature by methanotrophic bacteria, which consume methane gas as …

In this review, we describe recent research developments into radiation damage effects in
macromolecular X-ray crystallography observed at synchrotrons and X-ray free electron …

Serial femtosecond crystallography has opened up many new opportunities in structural
biology. In recent years, several approaches employing light-inducible systems have …

Isopenicillin N synthase (IPNS) catalyzes the unique reaction of l-δ-(α-aminoadipoyl)-l-
cysteinyl-d-valine (ACV) with dioxygen giving isopenicillin N (IPN), the precursor of all …

Conspectus Rigorous substrate selectivity is a hallmark of enzyme catalysis. This selectivity
is generally ascribed to a thermodynamically favorable process of substrate binding to the …

Nowadays, the vastly increasing demand for novel biotechnological products is supported
by the continuous development of biocatalytic applications that provide sustainable green …

Inspiration from natural enzymes enabling creationary catalyst design is appealing yet
remains extremely challenging for selective methane (CH 4) oxidation. This study presents …