The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Background Adolescence represents a period of development during which critical
biological, as well as social and cognitive, changes occur that are necessary for the …

A comprehensive account of the causes of alcohol misuse must accommodate individual
differences in biology, psychology and environment, and must disentangle cause and effect …

Endogenous retroviruses (ERVs) have contributed to more than 8% of the human genome.
The majority of these elements lack function due to accumulated mutations or internal …

Understanding the psychological mechanisms and underlying neurobiology of relapse
behavior is essential for improving the treatment of addiction. Because the neurobiology of …

Excessive alcohol consumption is one of the main causes of death and disability worldwide.
Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of …

Imaging genetics offers the possibility of detecting associations between genotype and brain
structure as well as function, with effect sizes potentially exceeding correlations between …

Alcohol is a widely consumed drug that can lead to addiction and severe brain damage.
However, alcohol is also used as self-medication for psychiatric problems, such as …

Findings from animal experiments are often difficult to transfer to humans. In this perspective
article I discuss two questions. First, why are the results of animal experiments often so …

Alcohol misuse and addiction are major international public health issues. Addiction can be
characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic …